The management of druginduced gingival overgrowth
: M. Mavrogiannis
: journal of clinical periodontology
Objectives: This review critically evaluates the different therapies that are available
to manage drug-induced overgrowth (DIGO).
Material and Methods: This review is based on literature identified using the online
databases MEDLINE and PUB MED. It is not a systematic review, but a conventional
review of the relevant literature.
Results: Patients benefit from a non-surgical approach if this can be delivered before
commencement of medication although in many instances this may not be practicable.
Systemic antibiotic usage has been evaluated in the management of ciclosporininduced
gingival overgrowth. Efficacy appears to be equivocal and long-term use is
undesirable. Surgical excision remains the main treatment option especially for
patients with severe overgrowth. Few studies have compared different techniques with
respect to recurrence rate or post-operative sequelae.
Conclusion: DIGO is a common clinical problem that often requires intervention.
Non-surgical techniques can limit the occurrence of this unwanted affect, reduce the
extent of plaque-induced gingival inflammation and reduce the rate of recurrence.
Wherever possible this management strategy should be adopted first. Surgical
treatment is often the most reliable option and scalpel gingivectomy remains the
treatment of choice. Further investigations are required to develop appropriate
management strategies to prevent recurrence of DIGO.
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