Microbial colonization patterns predict the outcomes of surgical treatment of intrabony defects
: Lisa Heitz-Mayfield
: Blackwell Synergy
Aim: To explore the impact of bacterial load and microbial colonization patterns on
the clinical outcomes of periodontal surgery at deep intrabony defects.
Materials and Methods: One hundred and twenty-two patients with advanced
chronic periodontitis and at least one intrabony defect of 43mm were recruited in 10
centres. Before recruitment, the infection control phase of periodontal therapy was
completed. After surgical access and debridement, the regenerative material was
applied in the test subjects, and omitted in the controls. At baseline and 1 year
following the interventions, clinical attachment levels (CAL), pocket probing depths
(PPD), recession (REC), full-mouth plaque scores and full-mouth bleeding scores were
assessed. Microbial colonization of the defect-associated pocket was assessed using a
DNAÃ¢â‚¬â€œDNA checkerboard analysis.
Results: Total bacterial load and counts of red complex bacteria were negatively
associated with CAL gains 1 year following treatment. The probability of achieving
above median CAL gains (43 mm) was significantly decreased by higher total bacterial
counts, higher red complex and T. forsythensis counts immediately before surgery.
Conclusions: Presence of high bacterial load and specific periodontal pathogen
complexes in deep periodontal pockets associated with intrabony defects had a
significant negative impact on the 1 year outcome of surgical/regenerative treatment.
Daftar copy :
||Ruang Referensi - Perpustakaan FKIK
Diproses dalam : 0.15709900856018 detik