Areview of the effects of stannous fluoride on gingivitis
: Blackwell Synergy
Aim: To review the literature on the effects of stannous fluoride on gingivitis.
Material and Methods: The Medline and cochrane central register of controlled
trials were searched up to August 2005 to identify appropriate studies. The primary
outcome measure was gingivitis.
Results: Independent screening of titles and abstracts of 542 papers resulted in 36
publications (inter-reviewer eÃ‹â€ score of 0.76), out of which 15 papers finally fulfilled the
criteria of eligibility. For SnF2 dentifrices, a statistically significant reduction in
gingivitis was noted in comparison with control (weighted mean difference (WMD) of
0.15 (gingival index) and 0.21 (gingivitis severity index) (test for heterogeneity
po0.00001, I2591.1% and p50.03, I2580.1%, respectively)). With regard to
plaque reduction inconsistent results existed. On using the plaque index no differences
were found, whereas meta-analysis of the Turesky index provided a WMD of 0.31
(p50.01, test for heterogeneity po0.0001, I2591.7%). Because of insufficient data,
a meta-analysis for SnF2 mouth rinse and dentifrice/mouthrinse formulations was not
Conclusions: The use of SnF2 dentifrices results in gingivitis and plaque reduction
when compared with a conventional dentifrice. The precise magnitude of this effect
was difficult to assess because of a high level of heterogeneity in study outcomes.
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