Severe periodontitis is associated with systemic inflammation and a dysmetabolic status: a caseÃ¢â‚¬â€œcontrol study
: Blackwell Synergy
Background and Aim: A cluster of metabolic factors defines a syndrome that
predisposes to diabetes and cardiovascular disease. Chronic infections such as
periodontitis might alter these individual metabolic factors and the systemic
inflammatory burden. The aim of this study was to investigate the association between
severe periodontitis and increase in inflammatory and metabolic risk factors for
Materials and Methods: We examined 302 patients with severe periodontitis and
183 healthy controls, and we collected a blood sample from each subject in order to
investigate differences in inflammatory (leukocyte numbers and differential counts)
and metabolic markers (lipids and glucose).
Results: After correcting for differences in age, gender, smoking and ethnicity,
periodontitis subjects exhibited a low-grade systemic inflammation (increased white
cell counts, 1.10 1.02 109/l, 95%CI 1.05Ã¢â‚¬â€œ1.15, p50.0001), dyslipidemia
[lower high-density lipoprotein cholesterol, 1.14 1.03 mmol/l, 95%CI 1.08Ã¢â‚¬â€œ1.20,
po0.0001 and higher low-density lipoprotein cholesterol, 1.12 1.03,
95%CI 1.05Ã¢â‚¬â€œ1.19, po0.0001) and increased non-fasting serum glucose levels
(1.04 1.01 mmol/l, 95%CI 1.02Ã¢â‚¬â€œ1.06, p50.01) when compared with controls.
The associations were confirmed in a subpopulation of Caucasian non-smokers.
A trend for a dose dependent effect of the number of periodontal pockets on the
tested inflammatory and metabolic markers was observed.
Conclusions: These data suggest a possible link between severe generalized
periodontitis, systemic inflammation and a dysmetabolic state in otherwise
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