Effect of non-surgical periodontal therapy on clinical and immunological response and glycaemic control in type 2 diabetic patients with moderate periodontitis
: Ana BeleÃ‚Â´n Navarro-Sanchez
: Blackwell Synergy
Objetives: The purpose of this study was to compare the local efficacy of
nonsurgical periodontal therapy between type 2 diabetic and non-diabetic patients
and the effect of periodontal therapy on glycaemic control.
Background: A complex two-way relationship exists between diabetes mellitus
Material and Methods: After selection, 20 subjects (10 diabetic and 10 non-diabetic)
underwent baseline examination, periodontal clinical study and biochemical
analysis of gingival crevicular fluid (GCF). After the pre-treatment phase,
subgingival scaling and root planing were performed. Subsequently, all subjects
continued the maintenance programme and were re-examined at 3 and 6 months.
Results: Diabetic and non-diabetic subjects responded well after therapy, showing
a very similar progression during the follow-up period. Both groups showed
clinically and immunologically significant improvements. Significant reductions were
also found in the total volume of GCF and levels of interleukin-1b and tumour necrosis
factor-a.Diabetic subjects showed an improvement in theirmetabolic control. The change
in glycosylated haemoglobin (HbA1C) was statistically significant at 3 and 6 months.
Conclusions: The clinical and immunological improvements obtained were
accompanied by a significant reduction in HbA1C values in type 2 diabetic
subjects. Larger studies are needed to confirm this finding and establish whether
periodontal therapy has a significant effect on glycaemic control.
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