Prevalence ofOPGand IL-1 gene polymorphisms in chronic periodontitis
: Blackwell Synergy
Aim: To investigate the association of polymorphisms in the osteoprotegerin (OPG)
and interleukin 1 (IL-1) genes with chronic periodontitis (CP).
Material and Methods: One hundred and ninety-four individuals (97 CP patients,
97 controls) were genotyped for the OPG polymorphisms Lys3Asn and Met256Val
and for the IL-1 polymorphisms IL-1A (889C/T) and IL-1B (13953C/T).
Results: The homozygous variants coding for Lys3 were present at a higher
frequency, whereas Asn3 and Met256 were present at a lower frequency in CP
patients/controls (Lys3: 31%/25%, Asn3: 23%/32% and Met256: 66%/73%).
Heterozygosity for Lys3Asn was observed at a higher frequency in CP patients/
controls (46%/43%). Homozygosity for the Val256 genotype was observed in two CP
patients (one in controls). Met256Val heterozygosity was more prevalent in CP
patients/controls (32%/20%). All differences were statistically not significant between
CP patients and controls. In contrast, both IL-1 polymorphisms were statistically
significant. The heterozygous variant for IL-1A was present in 32% of the CP patients
and in 20% of the controls (homozygosity (patients/controls) CC: 10%/21% and
TT: 55%/33%). Heterozygosity for IL-1B was observed in 37% of the CP patients
versus 34% in the controls (homozygosity (patients/controls) CC: 26%/57% and TT:
Conclusion: While the association between the IL-1 polymorphisms and CP was
confirmed, no association between the OPG polymorphisms and CP could be found.
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