Inflammatory mediator release following bone grafting in humans: a pilot study
: Rhonda D. Preston
: Blackwell Synergy
Aim: The aim of this pilot study was to track markers of periodontal inflammation and
bone resorption associated with decalcified freeze-dried bone allografts.
Material and Methods: Eleven subjects completed standardized treatment of
intrabony defects X3mm with allografts. Gingival crevicular fluid was collected from
the defect site and an adjacent interproximal site within the surgical field at baseline,
2, 4, and 8 weeks post-operatively, and analysed for biochemical markers of
inflammation/bone resorption. Probing depth, recession, bleeding on probing,
plaque, and 6-month radiographic bone height change were measured.
Results: Both prostaglandin E2 (p50.007) and bone-specific type 1 collagen
(p50.01) increased in crevicular fluid after 2 weeks in the bone graft sites. Matrix
metalloproteinase-9 levels remained constant over time. There were positive
correlations between prostaglandin levels during the first 8 weeks and bone height
change over 6 months.
Conclusions: Periodontal bone grafts stimulate an inflammatory response during the
first 2 weeks post-operatively, and the potential negative effects of inhibiting
prostaglandins post-operatively should be investigated further.
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