Effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontitis and coronary artery disease
: GuÃ‚Â¨ lay TuÃ‚Â¨ ter
: Blackwell Synergy
Objectives: This study evaluated the effects of scaling and root planing (SRP) sub-antimicrobial dose doxycycline (SDD) on gingival crevicular fluid (GCF) levels of
matrix metalloproteinase (MMP) -1, -8, -13 and on serum levels of high-sensitivity
C-reactive protein (HsCRP) and lipid fractions in patients with both chronic
periodontitis (CP) and coronary artery disease (CAD).
Material and Methods: Thirty-six patients were randomly distributed into two
groups (Placebo or SDD; 6 weeks) and both received two regimens of SRP. At baseline
and 6 weeks, GCF and blood were collected and clinical indices were recorded.
MMPs, HsCRP and lipid fractions were assayed.
Results: There were statistically significant improvements for all clinical parameters,
GCF volumes, GCF MMPs and serum levels of HsCRP, apolipoprotein-A (APO-A),
high-density lipoprotein (HDL) and lipoprotein-a between pre- and post-treatment in
both groups. Between groups, there were statistically significant greater improvements
in pocket depth (PD), gingival index (GI), APO-A and HDL, favouring the group
receiving SDD adjunctive to SRP (po0.05).
Conclusion: Greater improvement was detected for PD and GI, and for serum levels
of APO-A and HDL cholesterol when using SRP1SDD compared with SRP1placebo
in this study. An investigation with larger numbers of patients and a longer duration of
drug treatment is needed to confirm these preliminary findings.
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