Periodontal disease increases the risk of severe pre-eclampsia among pregnant women
: Blackwell Synergy
Aim: To evaluate the possible link between the severity of periodontal disease and
pre-eclampsia and to correlate this link to clinical periodontal parameters and
interleukin (IL)-1b, tumour necrosis factor-a (TNF-a), and prostaglandins (PGE2)
levels in both gingival crevicular fluid (GCF) and serum.
Material and Methods: Fifty-nine pregnant women (20 mild pre-eclampsia, 18
severe pre-eclampsia, and 21 healthy pregnant women) were included in the study.
Dental and periodontal recordings as well as GCF and blood samples were obtained
within 48 h preceding delivery.
Results: The results of multivariate logistic regression showed a highly significant
association between mild to severe pre-eclampsia and severe periodontal disease
(po0.001). After adjusting for potential confounders (smoking, body weight,
socioeconomic status, education level, and age), severe pre-eclamptic women were
3.78 (1.77Ã¢â‚¬â€œ12.74) times more likely to present severe periodontal disease than
normotensive pregnant women. This odds ratio (OR) was 2.43 (1.13Ã¢â‚¬â€œ8.19) for mild
pre-eclamptic women. IL-1b, TNF-a, and PGE2 levels in both serum and GCF were
also significantly higher in the pre-eclamptic groups than the normotensive women.
Conclusions: These results indicate that the presence and severity of periodontal
disease seems to increase the risk for not only the occurrence but also the severity
of pre-eclampsia in pregnant women.
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