Effect of constant strain rate, composed of varying amplitude and frequency, of early loading on peri-implant bone (re)modelling
: Blackwell Synergy
Aim: Examine the effect of varying components of strain rate Ã¢â‚¬â€œ amplitude versus
frequency Ã¢â‚¬â€œ while maintaining a constant strain rate of early controlled mechanical
loading on implant stability, peri-implant bone mass and bone-to-implant contact.
Material and Methods: Three groups of guinea-pigs received TiO2-blasted implants
in both tibiae. One week after installation test implants were loaded 5 days/week
during 4 weeks. The contra-lateral implants were the unloaded controls. Strain rate was
kept constant (1600 me/s), while amplitude and frequency were varied per group.
Implant stability was followed by resonance frequency analysis. Animals were
sacrificed, and ground sections were prepared to rate bone-to-implant contact and bone
Results: All implants (n578) integrated uneventfully. A significant positive effect
(p50.03) of early loading on bone mass was observed in the distal medullar cavity. A
significant difference in bone mass between test and control implants was evidenced
between the groups (p50.03 and 0.04). A significant increase in implant stability and
bone-to-implant contact could not be shown.
Conclusions: Early controlled stimulation of peri-implant bone is related to
amplitude/frequency and not to strain rate as such, considering a constant stimulation
time. An increase of bone mass around early-loaded implants was shown. This cortical
bone model is most sensitive to low-frequency/high-amplitude stimulation.
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