Periodontitis is characterized by elevated PAI-1 activity
: Blackwell Synergy
Objectives: Periodontitis is a chronic infectious disease and has been associated with
cardiovascular diseases (CVD). We investigated whether plasma levels of markers of
a prothrombotic state were elevated in patients with periodontitis in comparison with
Materials and methods: Untreated patients with moderate (n553) and severe
periodontitis (n538) and healthy controls (n539) were recruited. Levels of
von Willebrand factor (vWF), prothrombin fragment 112 (F112), plasminogen
activator inhibitor-1 (PAI-1) activity and D-dimer were measured as markers of a
Results: The erythrocyte sedimentation rate (ESR), plasma C-reactive protein (CRP)
and leucocyte counts (WBC) were significantly higher in patients with periodontitis.
No statistically significant difference was found among the three groups for vWF
(p50.264), F112 (p50.295) and D-dimer (p50.572). However, PAI-1 was clearly
elevated in the severe periodontitis group (p50.001), even after adjusting for potential
confounding factors (padj50.004). Moreover, more patients than controls were having
vWF and PAI-1 levels above the respective population medians.
Conclusions: In periodontitis, elevated levels of PAI-1 activity are observed
compared with healthy controls. This may increase the potential for impaired
fibrinolysis, a condition that results in a prothrombotic state. We suggest that this state,
if left untreated, may contribute to an increased risk for CVD.
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