Clinical models that objectively evaluate interproximal plaque based on total protein concentration
: Blackwell Synergy
Aim: To establish clinical models that accurately and objectively assess the levels of
interproximal plaque (IPP) by measuring the total protein concentration.
Material and Methods: The multiple treatment (MTM) and single-treatment models
(STM) were designed as randomized, double-blinded, crossover studies whereby IPP
was collected using floss. The total protein concentration in the plaque was then
measured using a fluorescence microplate assay. To demonstrate sensitivity, the levels
of residual IPP were compared for two distinctly different plaque removal routines:
brushing versus brushing1flossing.
Results: Eighteen subjects completed the study for the MTM, while 16 participants
completed the study for the STM. The results showed that both models were able to
distinguish between treatments. Moreover, fundamental profiles were established that
describe the mean changes in the IPP concentration over time and by treatment.
Finally, a comparison between our results and a direct measure of IPP, i.e., plaque
weight, demonstrated the potential of using protein as a quantitative means to assess
Conclusion: The MTM and STM provide an objective, quantitative assessment of IPP
based on the total protein concentration in plaque.
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