Polymorphisms in the CD14 and IL-6 genes associated with periodontal disease
: Tellervo Tervonen
: Blackwell Synergy
Aim: To compare the frequencies of cytokine and receptor molecule genotypes in
patients with chronic periodontitis with the corresponding frequencies in a reference
population and to study the relationship between periodontal disease severity and
polymorphisms in the studied genes.
Subjects and methods: CD14, IL-6, TNF-a, IL-10, IL-1a, IL-1b, and TLR-4
polymorphisms of 51 periodontitis patients were studied using polymerase chain
reaction. The genotype frequencies in the periodontitis patients and a reference
population (n5178) were compared. Probing pocket depth (PD), periodontal
attachment level (AL), and alveolar bone level (BL) were related to the genotypes.
Results: No statistically significant differences could be found between the
frequencies of the cytokine genotypes in the periodontitis patients and in the reference
group. The extent of periodontal disease was higher in subjects with the T-containing
genotype of CD14260 and the GG genotype of IL-6174 when compared with the
extent in the rest of the group. Subjects carrying the composite genotype of the above
two were most severely affected by periodontal disease.
Conclusion: According to the present results, an evident association exists between
the carriage of the T-containing genotype of CD14260 and the GG genotype of
IL-6174 and the extent periodontal disease.
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