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The new concept of periodontal disease pathogenesis requires new and novel therapeutic strategies
Penulis
: Martin A. Taubman
Edisi
: 5
Editor
:
Collation
:
Subyek
:
Penerbit
: Blackwell Synergy
Tahun
: 2007
ISBN
:
Call Number
:
Ringkasan :
In this issue Bostanci et al. (2007) demonstrate that receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG) were oppositely regulated in gingival crevice fluid (GCF) from periodontitis patients. RANKL, RANK and OPG are key molecules that regulate osteoclast recruitment, differentiation and activation. New concepts of the pathogenesis of periodontitis have implicated inflammation triggered by host immune response to periodontal biofilm microorganisms(s) in disease. Host response to bacteria involves activation of T and B cells in the inflammatory infiltrate which bear abundant RANKL that promotes osteoclastic bone resorption. Periodontal tissue destruction can be ameliorated by immunobiological interference with immune cell RANKL expression or function. The new disease concepts provide a foundation to build biological approaches to target RANKL production in periodontal lesions.

Daftar copy :
No. Barcode Lokasi No. Rak Ketersediaan
1 08194340 Ruang Referensi - Perpustakaan FKIK 01 TIDAK DIPINJAMKAN

 

Diproses dalam : 0.15429711341858 detik
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