Gingival crevicular fluid interleukin-1 b, prostaglandin E2 and periodontal status in a community population
: Blackwell Synergy
Aim: Interleukin-1 b (IL-1b) and prostaglandin E2 (PGE2) are key inflammatory
mediators involved in periodontal disease. The purposes of this molecular crosssectional
epidemiological study were to investigate relationships in a community
sample between mean concentrations of IL-1b and PGE2 in gingival crevicular fluid
(GCF) and (1) clinical periodontal signs and (2) risk factors of host inflammatory
response and/or periodontal disease.
Material and Methods: The sample comprised 6277 community-dwelling adults
aged 52Ã¢â‚¬â€œ74 years enrolled in the Atherosclerosis Risk in Communities (ARIC) study.
IL-1b and PGE2 concentrations were measured using enzyme-linked immunosorbent
assay. Person-level summary variables were computed for maximum pocket depth
(MaxPD), maximum clinical attachment level (MaxCAL) and presence/absence of
bleeding on probing (BOP). Mean GCF IL-1b and PGE2 concentrations were
dependent variables in multiple linear regression models with periodontal measures
and covariates as explanatory variables.
Results: Both GCF IL-1b and PGE2 were positively related to MaxPD and BOP in
multiple regression models (po0.01). Increased levels of IL-1b and PGE2 were
associated with body mass index X30 kg/m2.
Conclusion: Higher levels of GCF IL-1b and PGE2 were significantly associated with
clinical signs of periodontal disease and independently related to patient-based
anthropomorphic measures, behaviours and exposures in community-dwelling adults.
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