Effect of smoking on serum RANKL and OPG in sex, age and clinically matched supportive-therapy periodontitis patients
: David F. Lappin
: Blackwell Synergy
Methods: The serum concentrations of receptor activator of nuclear factor kB ligand
(RANKL) and osteoprotegerin (OPG) in age- and sex-matched groups of smokers and
non-smokers with almost identical levels of periodontal disease were determined by an
enzyme-linked immunosorbent assay (ELISA).
We ensured that the 35 smokers were gender, age and clinically matched with a group
of 35 non-smokers (confirmed by cotinine immunoassay) from the same population of
maintained patients with susceptibility to periodontitis.
Results: Cigarette smoker patients tended to have lower serum concentrations of
RANKL and OPG than non-smoker patients. While no statistically significant
difference was observed for RANKL, there were significant differences in the median
serum concentration of OPG (smokers 23.76 pM, non-smokers 59.28 pM) and the
ratio of serum concentrations of RANKL and OPG. Concentrations of OPG in the
smoker patients also had a statistically significant negative correlation with tobacco
Conclusion: Bone loss in smoker-related periodontitis patients may be partially
explained by suppression of OPG production.
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