Effect of platelet-rich plasma on the healing of intra-bony defects treated with a natural bone mineral and a collagen membrane
: Ferenc DoÃ‚Â¨ ri
: Blackwell Synergy
Background: Regenerative periodontal therapy with a combination of platelet-rich
plasma (PRP)1a natural bone mineral (NBM)1guided tissue regeneration (GTR) has
been shown to result in significantly higher probing depth reductions and clinical
attachment-level gains compared with treatment with open flap debridement alone.
However, at present, it is unknown to what extent the use of PRP may additionally
enhance the clinical outcome of the therapy compared with treatment with
Aim: To clinically compare treatment of deep intra-bony defects with
NBM1PRP1GTR with NBM1GTR.
Material and Methods: Thirty patients suffering from advanced periodontal disease,
and each of whom displayed one advanced intra-bony defect were randomly treated
with a combination of either NBM1PRP1collagen membrane (GTR) or NBM1GTR.
The following clinical parameters were evaluated at baseline and at 1 year after
treatment: plaque index, gingival index, bleeding on probing, probing depth (PD),
gingival recession and clinical attachment level (CAL). CAL changes were used as the
primary outcome variable.
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