Acute effects of periodontal therapy on bio-markers of vascular health
: Francesco DÃ¢â‚¬â„¢Aiuto
: Blackwell Synergy
Aim: We aimed to study the impact of periodontal therapy on several bio-markers
related to vascular health.
Material and Methods: Fifty-five consecutive subjects (age range 30Ã¢â‚¬â€œ64 years)
having severe periodontitis received an intensive session of periodontal therapy under
local anaesthesia and provided blood samples before and 1 and 7 and 30 days
following therapy. High-sensitivity assays were utilized to quantify serum
concentrations of inflammatory markers [interleukin(IL)-1b, tumour necrosis
factor-a], plasma haemostatic (D-dimer) and endothelial soluble markers [soluble
E-selectin(s-Es) and von Willebrand factor antigen (r-WF:Ag)].
Results: Periodontal therapy elicited a significant activation of the haemostatic
system (38% and 68% mean increases of plasma D-dimer 1 and 7 days after therapy,
respectively, po0.001), together with moderate endothelial dysfunction (10% and
30% mean increases at 24 h in plasma soluble E-selectin, po0.05 and von-Willebrand
factor, po0.01, respectively). D-Dimer and s-Es acute changes were significantly
correlated with periodontal treatment time (po0.05). Cigarette smoking status and
body mass index strongly influenced the acute release of IL-1b ( po0.05), D-dimer
( po0.01) and s-Es ( po0.01).
Conclusions: Periodontal therapy represents a novel and reliable non-drug-induced
model to investigate in vivo the interplay between inflammation, coagulation and
endothelial cell activation.
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