5-aminoisoquinolin-1(2 H)-one, a water-soluble poly (ADP-ribose) polymerase (PARP) inhibitor reduces the evolution of experimental periodontitis in rats
: Rosanna Di Paola
: Blackwell Synergy
Background: Poly (ADP-ribose) polymerase (PARP), a nuclear enzyme activated by
strand breaks in DNA, plays an important role in the tissue injury associated with
ischaemia-reperfusion and inflammation. Recent studies have demonstrated that PARP
activation plays a crucial role in the pathogenesis of acute periodontal injury.
Aim: We have investigated the effect of 5-aminoisoquinolin-1(2H)-one (5-AIQ), a
water-soluble PARP inhibitor, in a rat model of periodontitis.
Materials and Methods: Periodontitis was induced in rats by placing a 2/0 braided
silk ligature around the lower left first molar. At day eight, the gingivomucosal tissue
encircling the mandibular first molar was removed for biochemical and histological
Results and Conclusions: Ligation significantly induced an increased neutrophil
infiltration and a positive staining for PARP activation. Ligation significantly
increased Evans blue extravasation in gingivomucosal tissue and alveolar bone
destruction. Intraperitonial injection of 5-aminoisoquinolin-1(2H)-one (5-AIQ) (5 mg/
kg daily for eight days) significantly decreased all of the parameters of inflammation as
described above. This suggests that inhibition of PARP may represent a novel
approach for the treatment of periodontal disease.
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