Meta-analyses of studies of 0.2% delmopinol mouth rinse as an adjunct to gingival health and plaque control measures
: Blackwell Synergy
Background: Delmopinol is a third-generation anti-plaque agent used as a mouthwash
to reduce plaque and alleviate gingivitis.
Objective: To create an overview of the anti-plaque efficacy of 0.2% delmopinol as an
adjunct to normal oral hygiene measures by meta-analysis of completed clinical trials.
Materials and Methods: Eight double-blind, parallel-group studies were identified.
Study durations ranged from 8 to 24 weeks. Five studies (n5913) involved supervised
rinsing; three studies (n5467) involved unsupervised rinsing. These sets of trials were
analysed separately and in combination. Efficacy outcomes comprised modified plaque
index, modified gingival index (MGI) and gingival bleeding on probing (BOP).
Results: Delmopinol 0.2% was superior to placebo for the reduction of plaque scores
in both sets of studies. Effects on MGI and BOP were also better with delmopinol 0.2%
than with placebo. In most instances, 95% confidence intervals were wholly in favour
of delmopinol. Pooled analysis of all eight studies confirmed statistically significant
effects of delmopinol 0.2% compared with placebo ( po0.00001). Delmopinol met the
efficacy criteria of the American Dental Association in studies of extended duration.
Conclusion: Delmopinol 0.2% mouthwash is effective as an adjunct measure for reducing
plaque burden and indices of gingivitis, whether or not it is used under supervision.
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