Distribution of Genotypes of Porphyromonas gingivalisin Type 2 Diabetic Patients with Periodontitis in Mexico
: Claudia Davila-Perez
: Blackwell Synergy
Objective: To determine and compare the distribution of Porphyromonas gingivalis
fimA genotypes in type 2 diabetes mellitus (T2DM) patients affected by periodontitis,
using non-diabetic subjects with and without periodontitis as control groups.
Material and Methods: This study involved 75 subjects divided into three groups of
25 subjects each: Group 1 (non-T2DM without periodontitis), Group 2 (non-T2DM
with periodontitis) and Group 3 (T2DM with periodontitis). The outcome variable
was periodontitis, and explanatory variables were age, sex, T2DM and specific
P. gingivalis fimA genotypes.
Results: In non-T2DM subjects with healthy periodontal tissues, type I fimA was the
most frequently detected individually (40%) or in combinations (40%). In non-T2DM
subjects with periodontitis, the most frequently detected type was Ib individually
(20%) or in combinations (36%). In T2DM patients with periodontitis, the most
frequently detected types were types I (20%) and III (20%), but there was no statistical
difference (p40.05) with non-T2DM periodontitis subjects.
Conclusions: Type I genotype was more frequently detected in periodontally healthy
sites from non-T2DM subjects than in periodontitis sites from either subjects with or
without T2DM. However, in sites affected by periodontitis from T2DM subjects the
predominating types were I and III, which are less virulent strains of P. gingivalis.
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