A three-year prospective study of adult subjects with gingivitis II: microbiological parameters
: R. P. Teles, A. Bogren, M. Patel
: Blackwell Synergy
Aim: To investigate whether the clinical benefits obtained with a periodontal
prevention programme in subjects with periodontal health or minimal disease were
accompanied by beneficial changes in the subgingival microbiota.
Material and Methods: One hundred and twenty-four subjects completed the study.
Subjects were clinically and microbiologically monitored at baseline, 1, 2 and 3 years.
Subgingival plaque samples were taken from the mesiobuccal aspect of every tooth
and were analysed for the levels of 40 bacterial species using checkerboard DNAÃ¢â‚¬â€œ
DNA hybridization (total samples513,477). The mean counts of each of the 40 test
species were calculated for each subject at each time point. Significance of differences
over time was sought using the Friedman test. p values were adjusted for multiple
Results: All clinical parameters, at the microbiologically sampled sites, improved over
time. The clinical changes were accompanied by statistically significant decreases in
the mean counts of 35 of the 40 test species. Major reductions occurred by year 2 for
Actinomyces, Capnocytophaga, Campylobacter, Fusobacterium and Prevotella
species. At year 3, there was a modest re-growth of the majority of the species.
Conclusions: The clinical improvements obtained through preventive measures were
accompanied by a shift to a more host-compatible subgingival microbiota.
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