Histological and biomechanical evaluation of phosphorylcholine coated titanium implants
: Cristiano Susin
: Blackwell Synergy
Objective: Compounds considered for drug delivery from oral implant surfaces in
support of local bone formation might themselves influence osseointegration.
Phosphorylcholine (PC) polymers have been shown to enhance the biocompatibility of
medical devices and to serve as drug delivery systems. The objective of this study was
to evaluate local bone formation and osseointegration at PC and positively charged PC
(PC1)-coated endosseous implants in an established rabbit model.
Material and Methods: Sixteen adult female New Zealand White rabbits were used.
Eight animals received PC-coated and control titanium porous oxide surface implants
placed in the left and right distal femural condyle (trabecular bone) and proximal tibial
metaphysis (cortical bone) using aseptic routines. The remaining eight animals
similarly received PC1 and control implants. One implant was placed in each femural
condyle and two implants in each tibial metaphysis. Experimental and control implants
were alternated between the left and right hind legs. Fascia and skin were closed in
layers. The animals were euthanized following a 6-week healing interval for
biomechanical (removal torque) and histometric analyses.
Results: Peri-implant bone density was considerably greater at tibial compared with
femoral sites within as well as immediately outside the implant threads. However,
there were no significant differences in bone density among PC, PC1, and control
implants. Nevertheless, boneÃ¢â‚¬â€œimplant contact was significantly lower at PC compared
with PC1 and control implants in cortical bone (po0.05). Numerical differences in
trabecular bone did not reach statistical significance. The removal torque evaluation
revealed significantly lower values for PC compared with PC1 and control sites
Conclusion: The histometric and biomechanical analyses suggest that PC coating may
influence biological processes and ultimately osseointegration of endosseous implants.
Apparently, incorporation of cationic charges may reverse or compensate for this
scenario. Nevertheless, both PC coatings exhibited clinically acceptable osseointegration.
In perspective, PC technology appears to be a viable candidate delivery system for agents
in support of local bone formation at endosseous implant surfaces.
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