Comparative effect of tacrolimus 0.1% ointment and clobetasol 0.05% ointment in patients with oral lichen planus
: Giovanni Corrocher
: Blackwell Synergy
Background: Oral lichen planus (OLP) is considered to be an autoimmune disease
of unknown aetiology that affects the mucosae, especially the oral cavity.
Objective: We compared tacrolimus 0.1% ointment and clobetasol 0.05% ointment
for the treatment of OLP.
Patients and Methods: A total of 32 patients (20 females and 12 males; all white,
Italian origin, mean age of 43.6 18.4 years; 16 patients per treatment group) were
treated with tacrolimus or clobetasol ointment for 4 weeks in a randomized,
double-blind, clinical trial. Pain severity, burning sensation, and mucosal lesion
extension were assessed using a four-point scale.
Results: At the end of the treatment period, symptom scores were significantly lower
in the tacrolimus group than in the clobetasol group.
Conclusion: The results of this study suggest that tacrolimus 0.1% ointment is more
effective than clobetasol propionate 0.05% ointment in the treatment of OLP.
However, other studies are needed to confirm the effectiveness of this treatment before
it can be recommended for use in clinical practice.
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