Human leukocyte antigen polymorphism in chronic and aggressive periodontitis among Caucasians: a meta-analysis
: Blackwell Synergy
Aim: Multiple studies have reported associations between periodontitis and particular
human leukocyte antigens (HLA). Because associations are inconsistent, we
conducted a systematic literature review and a meta-analysis focusing on Caucasian
Material and Methods: A literature search reporting on the distribution of HLA class
I and II phenotypes in Caucasian patients with chronic periodontitis (CP) and
aggressive periodontitis (AP) was performed. Data sources included electronic
databases and bibliographies of published articles. Screening and data abstraction were
conducted independently by different reviewers.
Results: Out of 174 publications, 12 studies were considered to be suitable for metaanalysis.
In patients with CP, no significant HLA associations were found. Patients
with AP showed a positive association with HLA-A9 [odds ratio52.59 (95%
confidence interval 1.36Ã¢â‚¬â€œ4.83), p50.004] and HLA-B15 [1.90 (1.15Ã¢â‚¬â€œ3.16), p50.01]
as well as a negative association with HLA-A2 [0.72 (0.56Ã¢â‚¬â€œ0.94), p50.01] and -B5
[0.49 (0.30Ã¢â‚¬â€œ0.79), p50.004]. On grouping all patients into one periodontitis group
(AP1CP), the same deviations were confirmed with higher statistical significance. For
HLA-A9 and -B15, significant heterogeneity was found between the studies. No
significant associations were found with HLA class II antigens.
Conclusions: HLA-A9 and -B15 seem to represent susceptibility factors for AP
whereas HLA-A2 and -B5 are potential protective factors against periodontitis
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