Is there a temporal trend in the reported treatment efficacy of periodontal regeneration? A meta-analysis of randomizedcontrolled trials
: Blackwell Synergy
Background/Aim: The aim of study was to conduct a meta-analysis to investigate
whether or not there was a temporal trend in the treatment efficacy reported in the
randomized-controlled trials (RCTs) on guided tissue regeneration (GTR) or enamel
matrix protein derivatives (EMD) in the treatment of infrabony defects.
Material and Methods: The treatment outcomes were changes in probing pocket
depth (PPD) and clinical attachment level (CAL). Weighted multilevel and ordinary
regression analyses were performed to test the temporal relationship between treatment
effect difference or treatment effectiveness and publication years.
Results: For PPD reduction, non-significant positive relationships were found in the
treatment effect difference or treatment effect of both GTR and flap operation. For
CAL gain, a small positive relationship was found in the treatment effect difference,
but a significant positive trend in the treatment effect of flap operation was found. No
significant temporal trend was found in the treatment effect difference for EMD.
Conclusions: There was no evidence to support or refute a temporal trend in the
treatment effect of regenerative procedures, but a positive trend was observed in the
control group. These results suggest that only RCTs should be included in the
meta-analysis, as the treatment effect of the control group may not be constant.
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