Asepsis during periodontal surgery involving oral implants and the usefulness of peri-operative antibiotics: a prospective, randomized, controlled clinical trial
: Mahmoud Abu-TaÃ¢â‚¬â„¢a,
Objectives: This randomized clinical trial compares the usefulness of pre- and postoperative
antibiotics while strict asepsis was followed during periodontal surgery.
Material and Methods: Two groups of 40 consecutive patients each with fully or
partially edentulous jaws were enrolled. Antibiotics group (GrAB1): 23 men, mean
age 60, 128 implants, received oral amoxicillin 1 g, 1 h pre-operatively and 2 g for
2 days post-operatively. Non-antibiotics group (GrAB): 20 men, mean age 57,
119 implants, received no antibiotics. Bacterial samples were taken from the peri-oral
skin before and at the end of surgery. In 12 patients in each group, samples were also
taken from the nares. A VAS questionnaire evaluated symptoms of infection/
inflammation by both the patient and the periodontologist at suture removal.
Results: There were no significant differences between both groups, neither for the
clinical parameters nor for the microbiota. Staphylococcus aureus was detected in the
nares of one patient only. The patientsÃ¢â‚¬â„¢ subjective perception of post-operative
discomfort was significantly smaller in the group receiving antibiotics. Three patients
lost one or two implants.
Conclusions: Antibiotics do not provide significant advantages concerning postoperative
infections in case of proper asepsis. It also does not reduce peri-oral
microbial contamination. It does on the other hand reduce post-operative discomfort.
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