Effect of platelet-rich plasma on the healing of intrabony defects treated with an enamel matrix protein derivative and a natural bone mineral
: Ferenc DoÃ‚Â¨ ri, Dimitris Nikolidakis,
: Blackwell Synergy
Background: Regenerative periodontal surgery utilizing a combination of an enamel
matrix protein derivative (EMD) and a natural bone mineral (NBM) and platelet-rich
plasma (PRP) has been shown to enhance the outcomes of regenerative surgery
significantly. At present, it is unknown whether root conditioning with EMD, followed
by defect fill with a combination of NBM1PRP may additionally enhance the clinical
results obtained with EMD1NBM.
Aim: To compare clinically the treatment of deep intrabony defects with either
EMD1NBM1PRP or EMD1NBM.
Material and Methods: Twenty-six patients suffering from advanced chronic
periodontitis, and each of whom displayed one advanced intrabony defect were
randomly treated with either EMD1NBM1PRP (test) or EMD1NBM (control).
The following clinical parameters were evaluated at baseline and at 1 year after
treatment: plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing
depth (PD), gingival recession (GR) and clinical attachment level (CAL). The
primary outcome variable was CAL.
Results: Healing was uneventful in all patients. At 1 year after therapy, the test sites
showed a reduction in mean PD from 8.8 1.9mm to 3.1 0.9mm ( po0.001)
and a change in mean CAL from 10.8 2.0mm to 6.0 1.5mm ( po0.001). In
the control group the mean PD was reduced from 8.8 2.0mm to 2.8 1.6mm
( po0.001) and the mean CAL changed from 10.5 1.6mm to 5.5 1.4mm
( po0.001). CAL gains of X4mm were measured in 77% (i.e. in 10 out of 13 defects)
of the cases treated with EMD1NBM1PRP and in 100% (i.e. in all 13 defects) treated
with EMD1NBM. No statistically significant differences in any of the investigated
parameters were observed between the two groups.
Conclusions: Within its limits, the present study has shown that (i) 1 year after
regenerative surgery, both treatments resulted in statistically significant PD reductions and
CAL gains and (ii) the use of PRP failed to enhance the results obtained with EMD1NBM.
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