Periodontal healing following reconstructive surgery: effect of guided tissue regeneration using a bioresorbable barrier device when combined with autogenous bone grafting. A randomized controlled clinical trial
: Per Nygaard-ÃƒËœstby, Vibeke Bakke,
Objective: The objective of this randomized-controlled clinical trial was to evaluate
the adjunctive effect of guided tissue regeneration (GTR) using a bioresorbable
polylactic acid (PLA) barrier device when combined with autogenous bone grafting in
the treatment of deep intra-bony periodontal defects.
Material and Methods: Forty systemically healthy patients (20 females; mean age
53 years; non-smokers) participated in the study. Using a parallel-group study design,
one intra-bony defect in each of 20 subjects received GTR using the bioresorbable
PLA barrier device (Atrisorbs), combined with autogenous bone grafting. One
intra-bony defect in each of the remaining 20 subjects received bone grafting solo
(control). Treatments were evaluated at 9 months post-surgery.
Results: One patient (GTR) was withdrawn from the study due to circumstances
unrelated to the study. Eighty-nine per cent of the PLA barriers became exposed within
3 weeks following surgery. Pre-surgery probing depths for GTR and control intra-bony
defects averaged ( SE) 7.1 0.3 mm. Significant probing depth reduction (2.7 0.3
versus 2.4 0.4 mm), attachment-level gain (1.7 0.3 versus 1.7 0.5 mm), and
bone fill (1.2 0.4 versus 1.2 0.5 mm) were observed for the GTR and control sites,
respectively (p40.02). However, there were no statistically significant differences
between treatment protocols.
Conclusions: The results suggest that GTR using the bioresorbable PLA barrier
device does not provide additional value to reconstructive surgery including
autogenous bone grafting in intra-bony periodontal defects.
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